Association Between Uric Acid and Insulin-Like Growth Factor-1 in Type 2 Diabetes Mellitus

Abstract

Fang Liu,1 Yaru Wang,1 Qiang Zhao,2 Mei Zhang,3,4 Bo Ban3,4 1Department of Clinical Medicine, Jining Medical University, Jining, Shandong, 272067, People’s Republic of China; 2Department of Clinical Medicine, Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 3Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, 272029, People’s Republic of China; 4Chinese Research Center for Behavior Medicine in Growth and Development, Jining, Shandong, 272029, People’s Republic of ChinaCorrespondence: Bo BanDepartment of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, Jining, Shandong, 272029, People’s Republic of ChinaEmail [email protected]: This research examined the relationship between uric acid (UA) and insulin-like growth factor-1 (IGF-1) in patients with type 2 diabetes mellitus (T2DM).Methods: This study was a cross-sectional study that included 1230 Chinese patients with T2DM. We collected general information and laboratory indicators and calculated the standard deviation score of IGF-1 (IGF-1 SDS).Results: The univariate analysis results demonstrated a significant positive relationship between UA levels and IGF-1 SDS (P 4.17 mg/dl (β − 0.38,95% CI − 0.64, − 0.12; P=0.004).Conclusion: This study showed a nonlinear relationship between UA and IGF-1 in Chinese adults with T2DM. When the UA levels reached the inflection point, IGF-1 levels negatively correlated with the increase in UA. Further studies are needed to explore this relationship and mechanisms in the future.Keywords: uric acid, insulin-like growth factor-1, type 2 diabetes mellitus

Keywords

• uric acid
• insulin-like growth factor-1
• type 2 diabetes mellitus