Designing a Novel Nano-Vaccine against SARS-CoV-2

Ang Gao; Hui Liang; Qi Shen; Cheng Zhou; Xiao Min Chen; Jing Tian; Xueling Li; Zexi Liu; Jian Ni; Daxiang Cui

doi:10.5101/nbe.v12i4.p321-324

Nano Biomedicine and Engineering (Dec 2020)

Designing a Novel Nano-Vaccine against SARS-CoV-2

Ang Gao,
Hui Liang,
Qi Shen,
Cheng Zhou,
Xiao Min Chen,
Jing Tian,
Xueling Li,
Zexi Liu,
Jian Ni,
Daxiang Cui

Affiliations

Ang Gao: Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dong Chuan RD, Shanghai 200240, PR China
Hui Liang: National Engineering Research Center for Nanotechnology, 28 East Jiang Chuan Road, Shanghai 200241, China
Qi Shen: National Engineering Research Center for Nanotechnology, 28 East Jiang Chuan Road, Shanghai 200241, China
Cheng Zhou: National Engineering Research Center for Nanotechnology, 28 East Jiang Chuan Road, Shanghai 200241, China
Xiao Min Chen: National Engineering Research Center for Nanotechnology, 28 East Jiang Chuan Road, Shanghai 200241, China
Jing Tian: National Engineering Research Center for Nanotechnology, 28 East Jiang Chuan Road, Shanghai 200241, China
Xueling Li: National Engineering Research Center for Nanotechnology, 28 East Jiang Chuan Road, Shanghai 200241, China
Zexi Liu: National Engineering Research Center for Nanotechnology, 28 East Jiang Chuan Road, Shanghai 200241, China
Jian Ni: Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dong Chuan RD, Shanghai 200240, PR China
Daxiang Cui: Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dong Chuan RD, Shanghai 200240, PR China

DOI: https://doi.org/10.5101/nbe.v12i4.p321-324
Journal volume & issue: Vol. 12, no. 4
pp. 321 – 324

Abstract

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The new coronavirus SARS-CoV-2 has become a global pandemic, which has had a huge impact on the lives of people around the world and has caused huge impacts and losses on global economic development. To now, there is still no effective drug or therapy against coronavirus. A large number of studies have shown that vaccines are the ultimate weapon to eliminate major infectious diseases. The development of new vaccines against new coronaviruses is the best way to prevent new coronavirus infections. In this study, we developed a new vaccine against the new coronavirus by combining our self-developed nano adjuvant loaded with carnosine graphene oxide adjuvant with loaded with CpG molecule and RBD protein antigen. Our results showed that this vaccine can produce high titer anti-SARS-CoV-2 RBD antibody neutralizing SARS-CoV-2 in mice within 2 weeks.

Published in Nano Biomedicine and Engineering

ISSN: 2097-3837 (Print); 2150-5578 (Online)
Publisher: Tsinghua University Press
Country of publisher: China
LCC subjects: Science: Biology (General); Medicine
Website: https://www.sciopen.com/journal/2150-5578

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