Communications Biology (Apr 2022)
Identification of genetic effects underlying type 2 diabetes in South Asian and European populations
- Marie Loh,
- Weihua Zhang,
- Hong Kiat Ng,
- Katharina Schmid,
- Amel Lamri,
- Lin Tong,
- Meraj Ahmad,
- Jung-Jin Lee,
- Maggie C. Y. Ng,
- Lauren E. Petty,
- Cassandra N. Spracklen,
- Fumihiko Takeuchi,
- Md. Tariqul Islam,
- Farzana Jasmine,
- Anuradhani Kasturiratne,
- Muhammad Kibriya,
- Karen L. Mohlke,
- Guillaume Paré,
- Gauri Prasad,
- Mohammad Shahriar,
- Miao Ling Chee,
- H. Janaka de Silva,
- James C. Engert,
- Hertzel C. Gerstein,
- K. Radha Mani,
- Charumathi Sabanayagam,
- Marijana Vujkovic,
- Ananda R. Wickremasinghe,
- Tien Yin Wong,
- Chittaranjan S. Yajnik,
- Salim Yusuf,
- Habibul Ahsan,
- Dwaipayan Bharadwaj,
- Sonia S. Anand,
- Jennifer E. Below,
- Michael Boehnke,
- Donald W. Bowden,
- Giriraj R. Chandak,
- Ching-Yu Cheng,
- Norihiro Kato,
- Anubha Mahajan,
- Xueling Sim,
- Mark I. McCarthy,
- Andrew P. Morris,
- Jaspal S. Kooner,
- Danish Saleheen,
- John C. Chambers
Affiliations
- Marie Loh
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Weihua Zhang
- Department of Epidemiology and Biostatistics, Imperial College London
- Hong Kiat Ng
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Katharina Schmid
- Institute of Computational Biology, Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München
- Amel Lamri
- Department of Medicine, McMaster University
- Lin Tong
- The University of Chicago, Biological Sciences Division, Public Health Sciences
- Meraj Ahmad
- Genomic Research on Complex diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB)
- Jung-Jin Lee
- Translational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania
- Maggie C. Y. Ng
- Center for Genomics and Personalized Medicine Research, Center for Diabetes Research, Wake Forest School of Medicine
- Lauren E. Petty
- Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center
- Cassandra N. Spracklen
- Department of Genetics, University of North Carolina at Chapel Hill
- Fumihiko Takeuchi
- Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine
- Md. Tariqul Islam
- U Chicago Research Bangladesh
- Farzana Jasmine
- The University of Chicago, Biological Sciences Division, Public Health Sciences
- Anuradhani Kasturiratne
- Department of Public Health, Faculty of Medicine, University of Kelaniya
- Muhammad Kibriya
- The University of Chicago, Biological Sciences Division, Public Health Sciences
- Karen L. Mohlke
- Department of Genetics, University of North Carolina at Chapel Hill
- Guillaume Paré
- Population Health Research Institute, Hamilton Health Sciences and McMaster University
- Gauri Prasad
- Academy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus
- Mohammad Shahriar
- The University of Chicago, Biological Sciences Division, Public Health Sciences
- Miao Ling Chee
- Singapore Eye Research Institute, Singapore National Eye Centre
- H. Janaka de Silva
- Department of Medicine, Faculty of Medicine, University of Kelaniya
- James C. Engert
- Department of Medicine, McGill University
- Hertzel C. Gerstein
- Department of Medicine, McMaster University
- K. Radha Mani
- Genomic Research on Complex diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB)
- Charumathi Sabanayagam
- Singapore Eye Research Institute, Singapore National Eye Centre
- Marijana Vujkovic
- Department of Biostatistics and Epidemiology, University of Pennsylvania
- Ananda R. Wickremasinghe
- Department of Public Health, Faculty of Medicine, University of Kelaniya
- Tien Yin Wong
- Singapore Eye Research Institute, Singapore National Eye Centre
- Chittaranjan S. Yajnik
- Diabetes Unit, King Edward Memorial Hospital and Research Centre
- Salim Yusuf
- Department of Medicine, McMaster University
- Habibul Ahsan
- The University of Chicago, Biological Sciences Division, Public Health Sciences
- Dwaipayan Bharadwaj
- Academy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus
- Sonia S. Anand
- Department of Medicine, McMaster University
- Jennifer E. Below
- Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center
- Michael Boehnke
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Donald W. Bowden
- Department of Medicine, Mayo Hospital
- Giriraj R. Chandak
- Genomic Research on Complex diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB)
- Ching-Yu Cheng
- Singapore Eye Research Institute, Singapore National Eye Centre
- Norihiro Kato
- Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine
- Anubha Mahajan
- Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford
- Xueling Sim
- Saw Swee Hock School of Public Health, National University of Singapore
- Mark I. McCarthy
- Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford
- Andrew P. Morris
- Department of Biostatistics, University of Liverpool
- Jaspal S. Kooner
- Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust
- Danish Saleheen
- Center for Non-Communicable Diseases
- John C. Chambers
- Lee Kong Chian School of Medicine, Nanyang Technological University
- DOI
- https://doi.org/10.1038/s42003-022-03248-5
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 10
Abstract
Marie Loh, Weihua Zhang et al. use a genome-wide association study meta-analysis to examine variants associated with Type 2 diabetes (T2D) in South Asian and European ancestry cohorts. Their results provide further insights into the genetic mechanisms underlying T2D across ancestral populations.
