Nature Communications (Sep 2020)
Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy
- Soniya Bastola,
- Marat S. Pavlyukov,
- Daisuke Yamashita,
- Sadashib Ghosh,
- Heejin Cho,
- Noritaka Kagaya,
- Zhuo Zhang,
- Mutsuko Minata,
- Yeri Lee,
- Hirokazu Sadahiro,
- Shinobu Yamaguchi,
- Svetlana Komarova,
- Eddy Yang,
- James Markert,
- Louis B. Nabors,
- Krishna Bhat,
- James Lee,
- Qin Chen,
- David K. Crossman,
- Kazuo Shin-Ya,
- Do-Hyun Nam,
- Ichiro Nakano
Affiliations
- Soniya Bastola
- Department of Neurosurgery, University of Alabama at Birmingham
- Marat S. Pavlyukov
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
- Daisuke Yamashita
- Department of Neurosurgery, University of Alabama at Birmingham
- Sadashib Ghosh
- Department of Neurosurgery, University of Alabama at Birmingham
- Heejin Cho
- Research Institute for Future Medicine
- Noritaka Kagaya
- Biomedical Information Research Center, National Institute of Advanced Industrial Science and Technology
- Zhuo Zhang
- Department of Radiation Oncology, University of Alabama at Birmingham
- Mutsuko Minata
- Department of Neurosurgery, University of Alabama at Birmingham
- Yeri Lee
- Research Institute for Future Medicine
- Hirokazu Sadahiro
- Department of Neurosurgery, Yamaguchi University
- Shinobu Yamaguchi
- Department of Neurosurgery, University of Alabama at Birmingham
- Svetlana Komarova
- Department of Neurosurgery, University of Alabama at Birmingham
- Eddy Yang
- Department of Radiation Oncology, University of Alabama at Birmingham
- James Markert
- Department of Neurosurgery, University of Alabama at Birmingham
- Louis B. Nabors
- Department of Neurology, University of Alabama at Birmingham
- Krishna Bhat
- Department of Translational Molecular Pathology and Brain Tumor Center, The University of Texas, M.D. Anderson Cancer Center
- James Lee
- Department of Chemical and Biomolecular Engineering, Ohio State University
- Qin Chen
- Department of Neurosurgery, University of Alabama at Birmingham
- David K. Crossman
- Department of Genetics, University of Alabama at Birmingham
- Kazuo Shin-Ya
- Biomedical Information Research Center, National Institute of Advanced Industrial Science and Technology
- Do-Hyun Nam
- Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Ichiro Nakano
- Department of Neurosurgery, University of Alabama at Birmingham
- DOI
- https://doi.org/10.1038/s41467-020-18189-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Intratumoural spatial heterogeneity is crucial to enhance therapeutic resistance in glioblastoma. Here, the authors show a paracrine signaling mechanism where glioblastoma-initiating cells located in the tumour edge elevate their malignancy by interaction with core-located tumour cells.
