Nature Communications (Mar 2023)

Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence

  • Yinsheng Wu,
  • Lixu Tang,
  • Han Huang,
  • Qi Yu,
  • Bicheng Hu,
  • Gang Wang,
  • Feng Ge,
  • Tailang Yin,
  • Shanshan Li,
  • Xilan Yu

DOI
https://doi.org/10.1038/s41467-023-37094-8
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 21

Abstract

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Little is known about the role of glycolysis in cellular senescence. Here, authors report that glycolysis-derived serine biosynthesis activates PKM2 to phosphorylate histone H3T11, prevent cell senescence, and promote healthy aging.