Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer

Alexandre F. Aissa; Abul B. M. M. K. Islam; Majd M. Ariss; Cammille C. Go; Alexandra E. Rader; Ryan D. Conrardy; Alexa M. Gajda; Carlota Rubio-Perez; Klara Valyi-Nagy; Mary Pasquinelli; Lawrence E. Feldman; Stefan J. Green; Nuria Lopez-Bigas; Maxim V. Frolov; Elizaveta V. Benevolenskaya

doi:10.1038/s41467-021-21884-z

Nature Communications (Mar 2021)

Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer

Alexandre F. Aissa,
Abul B. M. M. K. Islam,
Majd M. Ariss,
Cammille C. Go,
Alexandra E. Rader,
Ryan D. Conrardy,
Alexa M. Gajda,
Carlota Rubio-Perez,
Klara Valyi-Nagy,
Mary Pasquinelli,
Lawrence E. Feldman,
Stefan J. Green,
Nuria Lopez-Bigas,
Maxim V. Frolov,
Elizaveta V. Benevolenskaya

Affiliations

Alexandre F. Aissa: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago
Abul B. M. M. K. Islam: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago
Majd M. Ariss: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago
Cammille C. Go: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago
Alexandra E. Rader: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago
Ryan D. Conrardy: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago
Alexa M. Gajda: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago
Carlota Rubio-Perez: Biomedical Genomics Lab, Institute for Research in Biomedicine (IRB)
Klara Valyi-Nagy: Department of Pathology, University of Illinois at Chicago
Mary Pasquinelli: Department of Medicine, Section of Hematology/Oncology, University of Illinois at Chicago
Lawrence E. Feldman: Department of Medicine, Section of Hematology/Oncology, University of Illinois at Chicago
Stefan J. Green: Genome Research Core, Research Resources Center, University of Illinois at Chicago
Nuria Lopez-Bigas: Biomedical Genomics Lab, Institute for Research in Biomedicine (IRB)
Maxim V. Frolov: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago
Elizaveta V. Benevolenskaya: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago

DOI: https://doi.org/10.1038/s41467-021-21884-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 25

Abstract

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It has been proposed that resistance to targeted therapies in non-small cell lung carcinoma (NSCLC) is due to a nonhomogeneous cell population. Here the authors analyse preclinical NSCLC models using single-cell RNA-seq and identify drug tolerant cell states and subpopulations, as well as associated genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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