Circular RNAs and Hepatocellular Carcinoma: New Epigenetic Players With Diagnostic and Prognostic Roles

Kedeerya Aishanjiang; Kedeerya Aishanjiang; Xin-dong Wei; Yi Fu; Xinjie Lin; Yujie Ma; Jiamei Le; Qiuqin Han; Xuan Wang; Xiaoni Kong; Jinyang Gu; Hailong Wu; Hailong Wu; Hailong Wu

doi:10.3389/fonc.2021.653717

Frontiers in Oncology (Apr 2021)

Circular RNAs and Hepatocellular Carcinoma: New Epigenetic Players With Diagnostic and Prognostic Roles

Kedeerya Aishanjiang,
Kedeerya Aishanjiang,
Xin-dong Wei,
Yi Fu,
Xinjie Lin,
Yujie Ma,
Jiamei Le,
Qiuqin Han,
Xuan Wang,
Xiaoni Kong,
Jinyang Gu,
Hailong Wu,
Hailong Wu,
Hailong Wu

Affiliations

Kedeerya Aishanjiang: Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Department of Collaborative Innovation Center for Biomedicine, Shanghai, China
Kedeerya Aishanjiang: Department of Transplantation, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
Xin-dong Wei: Department of General Surgery, The 81st Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Nanjing, China
Yi Fu: Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Department of Collaborative Innovation Center for Biomedicine, Shanghai, China
Xinjie Lin: Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Department of Collaborative Innovation Center for Biomedicine, Shanghai, China
Yujie Ma: Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Department of Collaborative Innovation Center for Biomedicine, Shanghai, China
Jiamei Le: Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Department of Collaborative Innovation Center for Biomedicine, Shanghai, China
Qiuqin Han: Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Department of Collaborative Innovation Center for Biomedicine, Shanghai, China
Xuan Wang: Department of General Surgery, The 81st Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Nanjing, China
Xiaoni Kong: Institute of Clinical Immunology, Department of Liver Diseases, Central Laboratory, ShuGuang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Jinyang Gu: Department of Transplantation, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
Hailong Wu: Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Department of Collaborative Innovation Center for Biomedicine, Shanghai, China
Hailong Wu: Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China
Hailong Wu: Collaborative Innovation Center for Biomedicine, Shanghai University of Medicine & Health Sciences, Shanghai, China

DOI: https://doi.org/10.3389/fonc.2021.653717
Journal volume & issue: Vol. 11

Abstract

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Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Due to the lack of potent diagnosis and prognosis biomarkers and effective therapeutic targets, the overall prognosis of survival is poor in HCC patients. Circular RNAs (circRNAs) are a class of novel endogenous non-coding RNAs with covalently closed loop structures and implicated in diverse physiological processes and pathological diseases. Recent studies have demonstrated the involvement of circRNAs in HCC diagnosis, prognosis, development, and drug resistance, suggesting that circRNAs may be a class of novel targets for improving HCC diagnosis, prognosis, and treatments. In fact, some artificial circRNAs have been engineered and showed their therapeutic potential in treating HCV infection and gastric cancer. In this review, we introduce the potential of circRNAs as biomarkers for HCC diagnosis and prognosis, as therapeutic targets for HCC treatments and discuss the challenges in circRNA research and chances of circRNA application.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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