Frontiers in Oncology (Apr 2022)
FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies
- Wenyue Shen,
- Wenyue Shen,
- Quanwei Zhou,
- Quanwei Zhou,
- Chenxi Peng,
- Chenxi Peng,
- Jiaheng Li,
- Jiaheng Li,
- Qizhi Yuan,
- Qizhi Yuan,
- Hecheng Zhu,
- Hecheng Zhu,
- Ming Zhao,
- Xingjun Jiang,
- Xingjun Jiang,
- Weidong Liu,
- Weidong Liu,
- Caiping Ren,
- Caiping Ren,
- Caiping Ren,
- Caiping Ren
Affiliations
- Wenyue Shen
- Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
- Wenyue Shen
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Quanwei Zhou
- Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
- Quanwei Zhou
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Chenxi Peng
- Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
- Chenxi Peng
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Jiaheng Li
- Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
- Jiaheng Li
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Qizhi Yuan
- Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
- Qizhi Yuan
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Hecheng Zhu
- Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, China
- Hecheng Zhu
- Changsha Kexin Cancer Hospital, Changsha, China
- Ming Zhao
- Changsha Kexin Cancer Hospital, Changsha, China
- Xingjun Jiang
- Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
- Xingjun Jiang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Weidong Liu
- Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, China
- Weidong Liu
- The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, School of Basic Medicine, Central South University, Changsha, China
- Caiping Ren
- Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
- Caiping Ren
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Caiping Ren
- Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, China
- Caiping Ren
- The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, School of Basic Medicine, Central South University, Changsha, China
- DOI
- https://doi.org/10.3389/fonc.2022.880077
- Journal volume & issue
-
Vol. 12
Abstract
FBXW7, a member of the F-box protein family within the ubiquitin–proteasome system, performs an indispensable role in orchestrating cellular processes through ubiquitination and degradation of its substrates, such as c-MYC, mTOR, MCL-1, Notch, and cyclin E. Mainly functioning as a tumor suppressor, inactivation of FBXW7 induces the aberrations of its downstream pathway, resulting in the occurrence of diseases especially tumorigenesis. Here, we decipher the relationship between FBXW7 and the hallmarks of cancer and discuss the underlying mechanisms. Considering the interplay of cancer hallmarks, we propose several prospective strategies for circumventing the deficits of therapeutic resistance and complete cure of cancer patients.
Keywords
