Journal of Allergy and Clinical Immunology: Global (May 2025)
Eosinophil ETosis and Charcot-Leyden crystals in Kimura disease
- Yuzaburo Inoue, MD, PhD,
- Hitoshi Ogata, MD,
- Yoshitake Sato, MD,
- Daigo Kato, MD, PhD,
- Kanako Mitsunaga, MD,
- Mamiko Saito, MD, PhD,
- Tatsuya Ishigaki, MD, PhD,
- Minako Tomiita, MD, PhD,
- Hiroshi Kuraishi, MD, PhD,
- Keisuke Ito, DDS,
- Shigeharu Ueki, MD, PhD
Affiliations
- Yuzaburo Inoue, MD, PhD
- Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan; Corresponding author: Yuzaburo Inoue, MD, PhD, Department of General Medical Science, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
- Hitoshi Ogata, MD
- Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan; Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan
- Yoshitake Sato, MD
- Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan
- Daigo Kato, MD, PhD
- Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan
- Kanako Mitsunaga, MD
- Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan
- Mamiko Saito, MD, PhD
- Department of Ophthalmology, Chiba Children's Hospital, Chiba, Japan
- Tatsuya Ishigaki, MD, PhD
- Department of Plastic Surgery, Chiba Children's Hospital, Chiba, Japan
- Minako Tomiita, MD, PhD
- Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan
- Hiroshi Kuraishi, MD, PhD
- Department of Pulmonology, Nagano Red Cross Hospital, Nagano, Japan
- Keisuke Ito, DDS
- Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Akita, Japan
- Shigeharu Ueki, MD, PhD
- Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Akita, Japan
- Journal volume & issue
-
Vol. 4,
no. 2
p. 100397
Abstract
Two cases of refractory Kimura disease that required treatment with biologic agents are reported. Their pathology suggests the involvement of eosinophil ETosis, which is active cell death producing Charcot-Leyden crystals.
