Eosinophil ETosis and Charcot-Leyden crystals in Kimura disease

Yuzaburo Inoue, MD, PhD; Hitoshi Ogata, MD; Yoshitake Sato, MD; Daigo Kato, MD, PhD; Kanako Mitsunaga, MD; Mamiko Saito, MD, PhD; Tatsuya Ishigaki, MD, PhD; Minako Tomiita, MD, PhD; Hiroshi Kuraishi, MD, PhD; Keisuke Ito, DDS; Shigeharu Ueki, MD, PhD

doi:10.1016/j.jacig.2024.100397

Journal of Allergy and Clinical Immunology: Global (May 2025)

Eosinophil ETosis and Charcot-Leyden crystals in Kimura disease

Yuzaburo Inoue, MD, PhD,
Hitoshi Ogata, MD,
Yoshitake Sato, MD,
Daigo Kato, MD, PhD,
Kanako Mitsunaga, MD,
Mamiko Saito, MD, PhD,
Tatsuya Ishigaki, MD, PhD,
Minako Tomiita, MD, PhD,
Hiroshi Kuraishi, MD, PhD,
Keisuke Ito, DDS,
Shigeharu Ueki, MD, PhD

Affiliations

Yuzaburo Inoue, MD, PhD: Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan; Corresponding author: Yuzaburo Inoue, MD, PhD, Department of General Medical Science, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
Hitoshi Ogata, MD: Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan; Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan
Yoshitake Sato, MD: Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan
Daigo Kato, MD, PhD: Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan
Kanako Mitsunaga, MD: Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan
Mamiko Saito, MD, PhD: Department of Ophthalmology, Chiba Children's Hospital, Chiba, Japan
Tatsuya Ishigaki, MD, PhD: Department of Plastic Surgery, Chiba Children's Hospital, Chiba, Japan
Minako Tomiita, MD, PhD: Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan
Hiroshi Kuraishi, MD, PhD: Department of Pulmonology, Nagano Red Cross Hospital, Nagano, Japan
Keisuke Ito, DDS: Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Akita, Japan
Shigeharu Ueki, MD, PhD: Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Akita, Japan

DOI: https://doi.org/10.1016/j.jacig.2024.100397
Journal volume & issue: Vol. 4, no. 2
p. 100397

Abstract

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Two cases of refractory Kimura disease that required treatment with biologic agents are reported. Their pathology suggests the involvement of eosinophil ETosis, which is active cell death producing Charcot-Leyden crystals.

Published in Journal of Allergy and Clinical Immunology: Global

ISSN: 2772-8293 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/journal-of-allergy-and-clinical-immunology-global

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