Elucidating the Antiviral Mechanism of Different MARCH Factors

Supawadee Umthong; Brian Lynch; Uddhav Timilsina; Brandon Waxman; Emily B. Ivey; Spyridon Stavrou

doi:10.1128/mBio.03264-20

mBio (Apr 2021)

Elucidating the Antiviral Mechanism of Different MARCH Factors

Supawadee Umthong,
Brian Lynch,
Uddhav Timilsina,
Brandon Waxman,
Emily B. Ivey,
Spyridon Stavrou

Affiliations

Supawadee Umthong: Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA
Brian Lynch: Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA
Uddhav Timilsina: Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA
Brandon Waxman: Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA
Emily B. Ivey: Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA
Spyridon Stavrou: ORCiD; Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA

DOI: https://doi.org/10.1128/mBio.03264-20
Journal volume & issue: Vol. 12, no. 2

Abstract

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This study examines the mechanism utilized by different MARCH proteins to restrict retrovirus infection. MARCH proteins block the incorporation of envelope glycoproteins to the budding virions.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal