Nature Communications (Apr 2019)

Adjustment for index event bias in genome-wide association studies of subsequent events

  • Frank Dudbridge,
  • Richard J. Allen,
  • Nuala A. Sheehan,
  • A. Floriaan Schmidt,
  • James C. Lee,
  • R. Gisli Jenkins,
  • Louise V. Wain,
  • Aroon D. Hingorani,
  • Riyaz S. Patel

DOI
https://doi.org/10.1038/s41467-019-09381-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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Different from GWAS for susceptibility to disease, GWAS for prognosis or survival may be vulnerable to selection bias. Here, Dudbridge et al present an approach to reduce index event bias in simulated and realistic situations, and apply it to GWAS of survival with idiopathic pulmonary fibrosis and Crohn’s disease prognosis.