SynOpen (Apr 2018)
An Efficient Method for the Preparation of N-Formamides using Propylphosphonic Anhydride (T3P®)
Abstract
Abstract The synthesis of N-formamides from aromatic amines and formic acid using propylphosphonic anhydride (T3P®) as a green coupling reagent is described. By using this method, aryl, heteroaryl and fluorinated aryl-containing formamides were synthesized in high yield and purity. The significant features of this method include easy work up, high purity and reduced toxicity of the reaction.
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