APL Materials (Dec 2014)

Multirate delivery of multiple therapeutic agents from metal-organic frameworks

  • Alistair C. McKinlay,
  • Phoebe K. Allan,
  • Catherine L. Renouf,
  • Morven J. Duncan,
  • Paul S. Wheatley,
  • Stewart J. Warrender,
  • Daniel Dawson,
  • Sharon E. Ashbrook,
  • Barbara Gil,
  • Bartosz Marszalek,
  • Tina Düren,
  • Jennifer J. Williams,
  • Cedric Charrier,
  • Derry K. Mercer,
  • Simon J. Teat,
  • Russell E. Morris

DOI
https://doi.org/10.1063/1.4903290
Journal volume & issue
Vol. 2, no. 12
pp. 124108 – 124108-8

Abstract

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The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.