Emerging radical rearrangement reactions: The 1,2-boron shift

Abstract

As the cross-coupling needs of chemists continue to grow for accessing increasingly complex targets, radical-based transformations have become mainstay methodologies for the discovery of new reactivity under mild and waste-limiting conditions. En route to such methodological advancements, the observation of the 1,2-boron shift a novel radical rearrangement in its application has generated a new cross-coupling methodology to access products that were previously inaccessible or otherwise cumbersome to make. The origins of this radical rearrangement along with the synthetic applications to organic chemistry are highlighted.

Keywords

• Radical chemistry
• Radical rearrangement
• 1,2-Boron shift
• Redox catalysis
• Redox-neutral
• Heterocycles