Quinazolin-4-ones, Thienopyrimidin-4-ones and Related Compounds: New Highly Active Powdery Mildewicides [1]

Abstract

In this short review, new quinazolinones and thieno-pyrimidinones with outstanding powdery mildew activity are introduced. The most important inventions of two major players in this field, DuPont and Syngenta, are presented and interesting strategies for the synthesis of 2-alkoxy-3-alkylthieno[2,3-d]pyrimidin-4-ones and related compounds are discussed in detail. The biological activities of selected compounds including the highlights, 6-bromo-2-propoxy-3-propylquinazolin-4-one and 6-chloro-2-propoxy-3-propylthieno[2,3-d]-pyrimidin-4-one are compared and discussed.

Keywords

• Powdery mildewicides
• Quinazolin-4-one
• Tetraalkylorthocarbonate
• Thieno[2,3-d]pyrimidin-4-one