Nature Communications (Dec 2021)
Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks
- Maik Müller,
- Fabienne Gräbnitz,
- Niculò Barandun,
- Yang Shen,
- Fabian Wendt,
- Sebastian N. Steiner,
- Yannik Severin,
- Stefan U. Vetterli,
- Milon Mondal,
- James R. Prudent,
- Raphael Hofmann,
- Marc van Oostrum,
- Roman C. Sarott,
- Alexey I. Nesvizhskii,
- Erick M. Carreira,
- Jeffrey W. Bode,
- Berend Snijder,
- John A. Robinson,
- Martin J. Loessner,
- Annette Oxenius,
- Bernd Wollscheid
Affiliations
- Maik Müller
- Department of Health Sciences and Technology (D-HEST), ETH Zurich, Institute of Translational Medicine (ITM)
- Fabienne Gräbnitz
- Department of Biology, ETH Zurich, Institute of Microbiology
- Niculò Barandun
- Department of Biology, ETH Zurich, Institute of Microbiology
- Yang Shen
- Institute of Food Nutrition and Health, Department of Health Sciences and Technology, ETH Zurich
- Fabian Wendt
- Department of Health Sciences and Technology (D-HEST), ETH Zurich, Institute of Translational Medicine (ITM)
- Sebastian N. Steiner
- Department of Health Sciences and Technology (D-HEST), ETH Zurich, Institute of Translational Medicine (ITM)
- Yannik Severin
- Institute of Molecular Systems Biology, Department of Biology, ETH Zurich
- Stefan U. Vetterli
- Chemistry Department, University of Zurich
- Milon Mondal
- Chemistry Department, University of Zurich
- James R. Prudent
- Centrose LLC
- Raphael Hofmann
- Laboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich
- Marc van Oostrum
- Department of Health Sciences and Technology (D-HEST), ETH Zurich, Institute of Translational Medicine (ITM)
- Roman C. Sarott
- Laboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich
- Alexey I. Nesvizhskii
- Department of Pathology, University of Michigan
- Erick M. Carreira
- Laboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich
- Jeffrey W. Bode
- Laboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich
- Berend Snijder
- Swiss Institute of Bioinformatics (SIB)
- John A. Robinson
- Chemistry Department, University of Zurich
- Martin J. Loessner
- Institute of Food Nutrition and Health, Department of Health Sciences and Technology, ETH Zurich
- Annette Oxenius
- Department of Biology, ETH Zurich, Institute of Microbiology
- Bernd Wollscheid
- Department of Health Sciences and Technology (D-HEST), ETH Zurich, Institute of Translational Medicine (ITM)
- DOI
- https://doi.org/10.1038/s41467-021-27280-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
The spatial organization of cell surface receptors is critical for cell signaling and drug action. Here, the authors develop an optoproteomic method for mapping surface protein interactions, revealing cellular responses to antibodies, drugs and viral particles as well as immunosynapse signaling events.
