Study on hypoglycemic effects of irradiated ginseng adventitious roots

Lu Zhang; Xin Qi; Xin-tong Lu; Cheng-bi Cui; Xue-feng Gao

Food Chemistry: X (Mar 2022)

Study on hypoglycemic effects of irradiated ginseng adventitious roots

Lu Zhang,
Xin Qi,
Xin-tong Lu,
Cheng-bi Cui,
Xue-feng Gao

Affiliations

Lu Zhang: Convergence College, Yanbian University, Yanji, Jilin 133000, China
Xin Qi: Pharma College, Yanbian University, Yanji, Jilin 133000, China
Xin-tong Lu: Agricultural College, Yanbian University, Yanji, Jilin 133000, China
Cheng-bi Cui: Convergence College, Yanbian University, Yanji, Jilin 133000, China; Pharma College, Yanbian University, Yanji, Jilin 133000, China; Agricultural College, Yanbian University, Yanji, Jilin 133000, China; Key Laboratory of Natural Medicine Research of Changbai Mountain, Ministry of Education, Yanbian University, Yanji, Jilin 133000, China; Corresponding authors at: Convergence College, Yanbian University, Yanji, Jilin 133000, China (C.-b. Cui).
Xue-feng Gao: Management College, Capital Normal University, Beijing, China; Corresponding authors at: Convergence College, Yanbian University, Yanji, Jilin 133000, China (C.-b. Cui).

Journal volume & issue: Vol. 13
p. 100234

Abstract

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We aimed to explore the effects of the 60Co-γ irradiated ginseng adventitious root (GAR) with different radiation doses on the hypoglycemic effects of its extract (GARSE) through in vivo and in vitro experiments. The total saponin of GARSE was increased by 4.50% after 5 kGy irradiation, and the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability was enhanced by 5.10%. At 50 μg/mL, GARSE irradiated by 5 kGy displayed superior protective effects on human glomerular mesangial cells (HMCs) with high glucose damage. After feeding type 1 diabetes mellitus (T1DM) mice with GARSE irradiated by 5 kGy at 500 mg/kg·BW for 4 weeks, the glucose values was decreased by 16.0% compared with the unirradiated. The Keap1/Nrf2/HO-1 pathway was activated and the oxidative stress was attenuated, which further alleviated T1DM.

Published in Food Chemistry: X

ISSN: 2590-1575 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply; Technology: Chemical technology: Food processing and manufacture
Website: https://www.journals.elsevier.com/food-chemistry-x

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