Non-invasive measurement of rat auditory evoked fields using an optically pumped atomic magnetometer: Effects of task manipulation
Yi Ruan,
Zhao Xiang,
Guanzhong Lu,
Yuhai Chen,
Yufei Liu,
Fan Liu,
Jiahao Wang,
Ying Zhang,
Jia Yao,
Yu Liu,
Qiang Lin
Affiliations
Yi Ruan
Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China; Corresponding authors. College of Science, Zhejiang University of Technology, No. 288, Liuhe Road, Hangzhou, Zhejiang Province, China.
Zhao Xiang
Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China
Guanzhong Lu
Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China
Yuhai Chen
Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China
Yufei Liu
Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China
Fan Liu
Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China
Jiahao Wang
Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China
Ying Zhang
Department of Endocrinology and Metabolism, Shaoxing Second Hospital, Shaoxing, 312000, China
Jia Yao
Department of Breast Surgery, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 311121, China
Yu Liu
Department of Breast Surgery, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 311121, China
Qiang Lin
Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China; Corresponding author.
Optically pumped magnetometers (OPMs) have become a favorable tool for magnetoencephalography (MEG) measurement, offering a non-invasive method of measurement. OPMs do not require cryogenic environments, sensors can be more closely aligned with the brain. We employed a passive single-stimulus paradigm in conjunction with OPMs with a sensitivity of 20 fT/ Hz to investigate the auditory response of rats to inter-stimulus interval (ISI) and frequencies, recording the rat auditory event-related magnetic fields (ERMFs). Our findings include: (1) Auditory evoked fields can be detected non-invasively by OPMs; (2) The amplitude of the rat auditory ERMFs varies with changes in ISI, with more pronounced amplitude changes observed after 5 s; (3) When the sound stimulus frequency is altered at the same ISI, the amplitude of the rats ERMFs changes with frequency, indicating significant differences in attention. Our method offers a valuable tool for the clinical application of a single stimulus paradigm and opens up a new avenue for research on the brain magnetic field detections.
