Nature Communications (Apr 2021)

Integrative reconstruction of cancer genome karyotypes using InfoGenomeR

  • Yeonghun Lee,
  • Hyunju Lee

DOI
https://doi.org/10.1038/s41467-021-22671-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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Karyotyping of cancer genomes at the base-level is technically challenging. Here, the authors introduce InfoGenomeR, an algorithm that can infer cancer genome karyotypes from whole-genome sequencing data, and test their model on breast, ovarian and brain cancer samples; and identify private and shared mutations between primary and metastatic cancer samples.