Nature Communications (Jan 2018)
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA
- Nina Rehage,
- Elena Davydova,
- Christine Conrad,
- Gesine Behrens,
- Andreas Maiser,
- Jenny E. Stehklein,
- Sven Brenner,
- Juliane Klein,
- Aicha Jeridi,
- Anne Hoffmann,
- Eunhae Lee,
- Umberto Dianzani,
- Rob Willemsen,
- Regina Feederle,
- Kristin Reiche,
- Jörg Hackermüller,
- Heinrich Leonhardt,
- Sonia Sharma,
- Dierk Niessing,
- Vigo Heissmeyer
Affiliations
- Nina Rehage
- Institute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität München
- Elena Davydova
- Group Intracellular Transport and RNA Biology, Institute of Structural Biology, Helmholtz Zentrum München
- Christine Conrad
- Institute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität München
- Gesine Behrens
- Institute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität München
- Andreas Maiser
- Center for Integrated Protein Science at the Department of Biology, Ludwig-Maximilians-Universität München
- Jenny E. Stehklein
- Research Unit Molecular Immune Regulation, Helmholtz Zentrum München
- Sven Brenner
- Research Unit Molecular Immune Regulation, Helmholtz Zentrum München
- Juliane Klein
- Institute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität München
- Aicha Jeridi
- Research Unit Molecular Immune Regulation, Helmholtz Zentrum München
- Anne Hoffmann
- Young Investigators Group Bioinformatics and Transcriptomics, Department Molecular Systems Biology, Helmholtz Centre for Environmental Research – UFZ
- Eunhae Lee
- Division of Cell Biology, La Jolla Institute for Allergy and Immunology
- Umberto Dianzani
- Department of Health Sciences, Universita’ del Piemonte Orientale
- Rob Willemsen
- CBG Department of Clinical Genetics, Erasmus MC
- Regina Feederle
- Monoclonal Antibody Core Facility and Research Group, Institute for Diabetes and Obesity, Helmholtz Zentrum München
- Kristin Reiche
- Bioinformatic Unit, Department of Diagnostics, Fraunhofer Institute for Cell Therapy and Immunology- IZI
- Jörg Hackermüller
- Young Investigators Group Bioinformatics and Transcriptomics, Department Molecular Systems Biology, Helmholtz Centre for Environmental Research – UFZ
- Heinrich Leonhardt
- Center for Integrated Protein Science at the Department of Biology, Ludwig-Maximilians-Universität München
- Sonia Sharma
- Division of Cell Biology, La Jolla Institute for Allergy and Immunology
- Dierk Niessing
- Group Intracellular Transport and RNA Biology, Institute of Structural Biology, Helmholtz Zentrum München
- Vigo Heissmeyer
- Institute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität München
- DOI
- https://doi.org/10.1038/s41467-017-02582-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
The RNA-binding proteins Roquin-1 and Roquin-2 are essential for immune cell function and postnatal survival in mice. Here, the authors identify NUFIP2 as a cofactor of Roquin; Roquin binds and stabilizes NUFIP2 in cells while NUFIP2 regulates Roquin mRNA target recognition.
