Molecular Neurodegeneration (Nov 2023)
Altered plasma protein profiles in genetic FTD – a GENFI study
- Abbe Ullgren,
- Linn Öijerstedt,
- Jennie Olofsson,
- Sofia Bergström,
- Julia Remnestål,
- John C. van Swieten,
- Lize C. Jiskoot,
- Harro Seelaar,
- Barbara Borroni,
- Raquel Sanchez-Valle,
- Fermin Moreno,
- Robert Laforce,
- Matthis Synofzik,
- Daniela Galimberti,
- James B. Rowe,
- Mario Masellis,
- Maria Carmela Tartaglia,
- Elizabeth Finger,
- Rik Vandenberghe,
- Alexandre de Mendonça,
- Pietro Tirabosch,
- Isabel Santana,
- Simon Ducharme,
- Chris R. Butler,
- Alexander Gerhard,
- Markus Otto,
- Arabella Bouzigues,
- Lucy Russell,
- Imogen J. Swift,
- Aitana Sogorb-Esteve,
- Carolin Heller,
- Jonathan D. Rohrer,
- Anna Månberg,
- Peter Nilsson,
- Caroline Graff,
- on behalf of the Genetic Frontotemporal Dementia Initiative (GENFI)
Affiliations
- Abbe Ullgren
- Swedish FTD Initiative
- Linn Öijerstedt
- Swedish FTD Initiative
- Jennie Olofsson
- Swedish FTD Initiative
- Sofia Bergström
- Swedish FTD Initiative
- Julia Remnestål
- Swedish FTD Initiative
- John C. van Swieten
- Department of Neurology, Erasmus Medical Centre
- Lize C. Jiskoot
- Department of Neurology, Erasmus Medical Centre
- Harro Seelaar
- Department of Neurology, Erasmus Medical Centre
- Barbara Borroni
- Department of Clinical and Experimental Sciences, Centre for Neurodegenerative Disorders, University of Brescia
- Raquel Sanchez-Valle
- Alzheimer’s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Institut d’Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona
- Fermin Moreno
- Department of Neurology, Cognitive Disorders Unit, Donostia University Hospital
- Robert Laforce
- Département Des Sciences Neurologiques, Clinique Interdisciplinaire de Mémoire, CHU de Québec, and Faculté de Médecine, Université Laval
- Matthis Synofzik
- Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen
- Daniela Galimberti
- Fondazione IRCCS Ospedale Policlinico
- James B. Rowe
- Department of Clinical Neurosciences, University of Cambridge
- Mario Masellis
- Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto
- Maria Carmela Tartaglia
- Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto
- Elizabeth Finger
- Department of Clinical Neurological Sciences, University of Western Ontario
- Rik Vandenberghe
- Department of Neurosciences, Laboratory for Cognitive Neurology, KU Leuven
- Alexandre de Mendonça
- Faculty of Medicine, University of Lisbon
- Pietro Tirabosch
- Fondazione IRCCS Istituto Neurologico Carlo Besta
- Isabel Santana
- Faculty of Medicine, University Hospital of Coimbra (HUC), Neurology Service, University of Coimbra
- Simon Ducharme
- Department of Psychiatry, McGill University Health Centre, McGill University
- Chris R. Butler
- Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford
- Alexander Gerhard
- Division of Neuroscience and Experimental Psychology, Wolfson Molecular Imaging Centre, University of Manchester
- Markus Otto
- Department of Neurology, University of Ulm
- Arabella Bouzigues
- Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square
- Lucy Russell
- Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square
- Imogen J. Swift
- Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square
- Aitana Sogorb-Esteve
- Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square
- Carolin Heller
- Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square
- Jonathan D. Rohrer
- Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square
- Anna Månberg
- Swedish FTD Initiative
- Peter Nilsson
- Swedish FTD Initiative
- Caroline Graff
- Swedish FTD Initiative
- on behalf of the Genetic Frontotemporal Dementia Initiative (GENFI)
- DOI
- https://doi.org/10.1186/s13024-023-00677-6
- Journal volume & issue
-
Vol. 18,
no. 1
pp. 1 – 12
Abstract
Abstract Background Plasma biomarkers reflecting the pathology of frontotemporal dementia would add significant value to clinical practice, to the design and implementation of treatment trials as well as our understanding of disease mechanisms. The aim of this study was to explore the levels of multiple plasma proteins in individuals from families with genetic frontotemporal dementia. Methods Blood samples from 693 participants in the GENetic Frontotemporal Dementia Initiative study were analysed using a multiplexed antibody array targeting 158 proteins. Results We found 13 elevated proteins in symptomatic mutation carriers, when comparing plasma levels from people diagnosed with genetic FTD to healthy non-mutation controls and 10 proteins that were elevated compared to presymptomatic mutation carriers. Conclusion We identified plasma proteins with altered levels in symptomatic mutation carriers compared to non-carrier controls as well as to presymptomatic mutation carriers. Further investigations are needed to elucidate their potential as fluid biomarkers of the disease process.
Keywords
