Frontiers in Pharmacology (Sep 2024)
Pharmacology of boldine: summary of the field and update on recent advances
- Juan C. Sáez,
- Justin C. Burrell,
- Justin C. Burrell,
- Catherine M. Cahill,
- D. Kacy Cullen,
- D. Kacy Cullen,
- Lakshmi A. Devi,
- Lakshmi A. Devi,
- Lakshmi A. Devi,
- Ryan J. Gilbert,
- Ryan J. Gilbert,
- Zachary A. Graham,
- Vadim J. Gurvich,
- Leif A. Havton,
- Leif A. Havton,
- Leif A. Havton,
- Ravi Iyengar,
- Ravi Iyengar,
- Rajesh Khanna,
- Edmund F. Palermo,
- Edmund F. Palermo,
- Mustafa Siddiq,
- Mustafa Siddiq,
- Carlos A. Toro,
- Carlos A. Toro,
- Carlos A. Toro,
- Walter Vasquez,
- Wei Zhao,
- Wei Zhao,
- Wei Zhao,
- Christopher P. Cardozo,
- Christopher P. Cardozo,
- Christopher P. Cardozo
Affiliations
- Juan C. Sáez
- Instituto de Neurociencias, Centro Interdisciplinario de Neurociencia, Universidad de Valparaíso, Valparaíso, Chile
- Justin C. Burrell
- Center for Neurotrauma, Neurodegeneration and Restoration, CMC VA Medical Center, Philadelphia, PA, United States
- Justin C. Burrell
- Department of Neurosurgery, Center for Brain Injury and Repair, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
- Catherine M. Cahill
- Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, United States
- D. Kacy Cullen
- Center for Neurotrauma, Neurodegeneration and Restoration, CMC VA Medical Center, Philadelphia, PA, United States
- D. Kacy Cullen
- Department of Neurosurgery, Center for Brain Injury and Repair, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
- Lakshmi A. Devi
- Department of Pharmacology and System Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Lakshmi A. Devi
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Lakshmi A. Devi
- Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Ryan J. Gilbert
- Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, United States
- Ryan J. Gilbert
- Albany Stratton VA Medical Center, New York, NY, United States
- Zachary A. Graham
- 0Healthspan, Resilience and Performance, Florida Institute for Human and Machine Cognition, Gainesville, FL, United States
- Vadim J. Gurvich
- 1Institute for Therapeutics Discovery and Development and Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN, United States
- Leif A. Havton
- Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Leif A. Havton
- 2Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Leif A. Havton
- 3Spinal Cord Damage Research Center, James J Peters VA Medical Center, New York, NY, United States
- Ravi Iyengar
- 4Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Ravi Iyengar
- 5Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Rajesh Khanna
- 6Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, United States
- Edmund F. Palermo
- Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, United States
- Edmund F. Palermo
- 7Materials Science and Engineering, Rensselaer Polytechnic Institute, New York, NY, United States
- Mustafa Siddiq
- 4Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Mustafa Siddiq
- 5Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Carlos A. Toro
- 3Spinal Cord Damage Research Center, James J Peters VA Medical Center, New York, NY, United States
- Carlos A. Toro
- 8Department of Medicine, Icahn School of Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Carlos A. Toro
- 9Department of Rehabilitation Medicine and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Walter Vasquez
- Instituto de Neurociencias, Centro Interdisciplinario de Neurociencia, Universidad de Valparaíso, Valparaíso, Chile
- Wei Zhao
- 3Spinal Cord Damage Research Center, James J Peters VA Medical Center, New York, NY, United States
- Wei Zhao
- 8Department of Medicine, Icahn School of Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Wei Zhao
- 9Department of Rehabilitation Medicine and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Christopher P. Cardozo
- 3Spinal Cord Damage Research Center, James J Peters VA Medical Center, New York, NY, United States
- Christopher P. Cardozo
- 8Department of Medicine, Icahn School of Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Christopher P. Cardozo
- 9Department of Rehabilitation Medicine and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- DOI
- https://doi.org/10.3389/fphar.2024.1427147
- Journal volume & issue
-
Vol. 15
Abstract
Over the past decade, boldine, a naturally occurring alkaloid found in several plant species including the Chilean Boldo tree, has garnered attention for its efficacy in rodent models of human disease. Some of the properties that have been attributed to boldine include antioxidant activities, neuroprotective and analgesic actions, hepatoprotective effects, anti-inflammatory actions, cardioprotective effects and anticancer potential. Compelling data now indicates that boldine blocks connexin (Cx) hemichannels (HCs) and that many if not all of its effects in rodent models of injury and disease are due to CxHC blockade. Here we provide an overview of boldine’s pharmacological properties, including its efficacy in rodent models of common human injuries and diseases, and of its absorption, distribution, pharmacokinetics, and metabolism.
Keywords
