Comparison of the effects of bepridil and aprindine for the prevention of atrial fibrillation after cardiac and aortic surgery: A prospective randomized study

Mahito Ozawa, MD; Takashi Komatsu, MD; Yoshihiro Sato, MD; Fusanori Kunugita, MD; Hideaki Tachibana, MD; Atsushi Tashiro, MD; Hitoshi Okabayashi, MD; Motoyuki Nakamura, MD,PhD

doi:10.1016/j.joa.2015.04.003

Journal of Arrhythmia (Oct 2015)

Comparison of the effects of bepridil and aprindine for the prevention of atrial fibrillation after cardiac and aortic surgery: A prospective randomized study

Mahito Ozawa, MD,
Takashi Komatsu, MD,
Yoshihiro Sato, MD,
Fusanori Kunugita, MD,
Hideaki Tachibana, MD,
Atsushi Tashiro, MD,
Hitoshi Okabayashi, MD,
Motoyuki Nakamura, MD,PhD

Affiliations

Mahito Ozawa, MD: Division of Cardioangiology, Nephrology and Endocrinology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine, Morioka, Japan
Takashi Komatsu, MD: Division of Cardioangiology, Nephrology and Endocrinology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine, Morioka, Japan
Yoshihiro Sato, MD: Division of Cardioangiology, Nephrology and Endocrinology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine, Morioka, Japan
Fusanori Kunugita, MD: Division of Cardioangiology, Nephrology and Endocrinology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine, Morioka, Japan
Hideaki Tachibana, MD: Division of Cardioangiology, Nephrology and Endocrinology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine, Morioka, Japan
Atsushi Tashiro, MD: Division of Cardioangiology, Nephrology and Endocrinology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine, Morioka, Japan
Hitoshi Okabayashi, MD: Department of Cardiovascular Surgery, Iwate Medical University School of Medicine, Morioka, Japan
Motoyuki Nakamura, MD,PhD: Division of Cardioangiology, Nephrology and Endocrinology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine, Morioka, Japan

DOI: https://doi.org/10.1016/j.joa.2015.04.003
Journal volume & issue: Vol. 31, no. 5
pp. 302 – 306

Abstract

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Background: Approximately one-third of the patients undergoing cardiovascular surgery reportedly experience paroxysmal atrial fibrillation (AF) during the postoperative period. However, the usefulness of antiarrhythmic drugs for preventing postoperative AF recurrence in the Japanese population has not been extensively studied. Methods: From a total of 118 patients who developed postoperative paroxysmal AF between April 2009 and March 2011, 72 patients (45 men, mean age 68±8 years) requiring treatment for postoperative AF due to symptoms lasting ≥30 min were enrolled to prospectively investigate the efficacy of oral bepridil (100 mg/day, n=37) or aprindine (40 mg/day, n=35). Result: The AF recurrence-free survival rates at 1, 3, 7, and 14 days were 100%, 94%, 57%, and 49%, respectively, in the aprindine group, and 100%, 97%, 86%, and 76%, respectively, in the bepridil group (P=0.028, aprindine vs. bepridil). Conclusion: Bepridil, at a fixed dose of 100 mg/day, was considered to be more effective than a routine dose of aprindine for the prevention of postoperative AF recurrence.

Published in Journal of Arrhythmia

ISSN: 1880-4276 (Print); 1883-2148 (Online)
Publisher: Wiley
Country of publisher: Australia
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://onlinelibrary.wiley.com/journal/18832148

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