Mechanochemical difluoromethylations of ketones

Abstract

We present a mechanochemical synthesis of difluoromethyl enol ethers. Utilizing an in situ generation of difluorocarbenes, ketones are efficiently converted to the target products under solvent-free conditions. The reactions proceed at room temperature and are complete within 90 minutes, demonstrating both efficiency and experimental simplicity.

Keywords

• ball milling
• difluorocarbene
• difluoromethylations
• difluoromethyl enol ether
• mechanochemistry