DIFFERENTIAL-DIAGNOSTIC CHARACTERISTICS OF INFILTRATIVE PULMONARY TUBERCULOSIS DEPENDING ON THE NATURE OF INFLAMMATORY TISSUE REACTION (PRODUCTIVE OR EXUDATIVE)

Abstract

Purpose: assessment of the free radical oxidation system and antioxidant protection, immune and cytokine status in patients with pulmonary infiltrative tuberculosis, depending on the type of inflammatory tissue reaction. Materials and Methods: the study included 60 patients with infiltrative pulmonary tuberculosis with exudative and productive type of inflammation.Statistical analysis of the data was performed using the program Statistica 6.0. Results: the patients with productive type of inflammation are mainly characterized by a limited process with poor bacterioexcretion, moderate disturbances in the free-radical oxidationsystem, antioxidant protection, immune and cytokine status. In patients with exudative type widespread destructive process with massive excretion of Mycobacterium tuberculosisprevails, as well as severe disturbances in the free-radical oxidationsystem, antioxidant protection, immune and cytokine status. Summary: the clinical and laboratory characteristics of infiltrative tuberculosis with different types of inflammatory tissue reaction should be considered duringprescription of pathogenetic treatment and prediction of the course and of the outcome of tuberculosis process.

Keywords

• infiltrative tuberculosis
• the nature of the inflammatory tissue reaction
• free radical oxidation
• immune status
• cytokine status