Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations

Abstract

Sequential cycloisomerizations of diynyl o-benzaldehyde substrates to access novel polycyclic cyclopropanes are reported. The reaction sequence involves initial Cu(I)-mediated cycloisomerization/nucleophilic addition to an isochromene followed by diastereoselective Pt(II)-catalyzed enyne cycloisomerization.

Keywords

• chemical diversity
• cycloisomerization
• cyclopropane
• diyne
• isochromene
• π-acid