Radiology Case Reports (Mar 2025)

Primary splenic diffuse large B-cell lymphoma presenting with a gastrosplenic fistula: Case report

  • Hurerah Nawaz,
  • Josh Greaser,
  • Irfan Amir Kazi,
  • Ayesha Nasrullah

Journal volume & issue
Vol. 20, no. 3
pp. 1359 – 1362

Abstract

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Primary splenic diffuse large B-cell lymphoma (PS-DLBCL) is a rare manifestation of malignant lymphoma. Although DLBCL is the most common subtype of non-Hodgkin lymphoma, primary splenic involvement is uncommon. Additionally, a gastrosplenic fistula at initial presentation is even more rare and poses a diagnostic challenge for the radiologist. The clinical and imaging picture can be identical to a splenic abscess with a secondary gastrosplenic fistula formation (GSF), leading to a diagnostic conundrum. Hence, radiologists need to be familiar with this entity for correct diagnosis and appropriate clinical management.

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