Assessing VEGF mRNA and miR-494 expression in peripheral blood collected from patients suffering from oral squamous cell carcinoma

Abstract

Introduction: Oral squamous cell carcinoma accounts for 2% of all cancers and also is one of the top 10 causes of death in humans. The goal of this article is to assess changes of VEGF mRNA and miR-494 expression. Materials and Methods: We chose 30 patients with OSCC and 30 healthy people (as a controlled group) and assess the rate of VEGF mRNA and miR-494 expression in peripheral blood with real-time PCR technique. Findings: VEGF mRNA marker was positive in 24 out of 30 patients. Also, miR-494 was positive in 20 out of 30 patients. Results: Overall based on this article’s findings, results could count as a diagnostic screening test for OSCC detection in early steps of cancer.

Keywords

• Oral squamous cell carcinoma
• Early diagnosis
• VEGF mRNA
• miR-494