LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense

Ai-Yu Gong; Yang Wang; Min Li; Xin-Tian Zhang; Silu Deng; Jessie M. Chen; Eugene Lu; Nicholas W. Mathy; Gislaine A. Martins; Juliane K. Strauss-Soukup; Xian-Ming Chen

doi:10.1128/mBio.02127-21

mBio (Oct 2021)

LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense

Ai-Yu Gong,
Yang Wang,
Min Li,
Xin-Tian Zhang,
Silu Deng,
Jessie M. Chen,
Eugene Lu,
Nicholas W. Mathy,
Gislaine A. Martins,
Juliane K. Strauss-Soukup,
Xian-Ming Chen

Affiliations

Ai-Yu Gong: Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA
Yang Wang: Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA
Min Li: Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA
Xin-Tian Zhang: Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA
Silu Deng: Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA
Jessie M. Chen: Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA
Eugene Lu: Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA
Nicholas W. Mathy: Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA
Gislaine A. Martins: Deptartments of Medicine and Biomedical Sciences, Research Division of Immunology Cedars-Sinai Medical Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Juliane K. Strauss-Soukup: Department of Chemistry, Creighton University College of Arts and Sciences, Omaha, Nebraska, USA
Xian-Ming Chen: ORCiD; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA

DOI: https://doi.org/10.1128/mBio.02127-21
Journal volume & issue: Vol. 12, no. 5

Abstract

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Epithelial cells along the mucosal surface provide the front line of defense against luminal pathogen infection in the gastrointestinal tract. These epithelial cells represent an integral component of a highly regulated communication network that can transmit essential signals to cells in the underlying intestinal mucosa that, in turn, serve as targets of mucosal immune mediators.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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