LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense
Ai-Yu Gong,
Yang Wang,
Min Li,
Xin-Tian Zhang,
Silu Deng,
Jessie M. Chen,
Eugene Lu,
Nicholas W. Mathy,
Gislaine A. Martins,
Juliane K. Strauss-Soukup,
Xian-Ming Chen
Affiliations
Ai-Yu Gong
Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA
Yang Wang
Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA
Min Li
Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA
Xin-Tian Zhang
Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA
Silu Deng
Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA
Jessie M. Chen
Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA
Eugene Lu
Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA
Nicholas W. Mathy
Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA
Gislaine A. Martins
Deptartments of Medicine and Biomedical Sciences, Research Division of Immunology Cedars-Sinai Medical Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Juliane K. Strauss-Soukup
Department of Chemistry, Creighton University College of Arts and Sciences, Omaha, Nebraska, USA
Epithelial cells along the mucosal surface provide the front line of defense against luminal pathogen infection in the gastrointestinal tract. These epithelial cells represent an integral component of a highly regulated communication network that can transmit essential signals to cells in the underlying intestinal mucosa that, in turn, serve as targets of mucosal immune mediators.
