Research progress on the correlation between osteopontin and non-small cell lung cancer

Abstract

Osteopontin (OPN) is a secreted phosphosylated protein, which is widely found in various tissues and body fluids. OPN involved in various physiological and pathological processes such as bone growth, wound healing and cell adhesion and migration. The integrin αvβ3 is the main receptor for OPN. Recent studies have shown that the high expression level of OPN is closely related to the invasive phenotype and poor prognosis of non-small cell lung cancer (NSCLC) . OPN is expected to become a potential serological biomarker and therapeutic drug target for the disease, which has gradually attracted the attention of researchers at home and abroad. Therefore, this paper presents the structural characteristics of OPN and its correlation with the occurrence, development and treatment prognosis of NSCLC.

Keywords

• osteopontin
• non-small cell lung cancer
• epithelial-mesenchymal transition
• signal pathway
• resistant mechanism
• integrin αvβ3