Functional role of the Frizzled linker domain in the Wnt signaling pathway

Seung-Bum Ko; Emiko Mihara; Yedarm Park; Kyeonghwan Roh; Chanhee Kang; Junichi Takagi; Injin Bang; Hee-Jung Choi

doi:10.1038/s42003-022-03370-4

Communications Biology (May 2022)

Functional role of the Frizzled linker domain in the Wnt signaling pathway

Seung-Bum Ko,
Emiko Mihara,
Yedarm Park,
Kyeonghwan Roh,
Chanhee Kang,
Junichi Takagi,
Injin Bang,
Hee-Jung Choi

Affiliations

Seung-Bum Ko: Department of Biological Sciences, Seoul National University
Emiko Mihara: Laboratory for Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Suita
Yedarm Park: Department of Biological Sciences, Seoul National University
Kyeonghwan Roh: Department of Biological Sciences, Seoul National University
Chanhee Kang: Department of Biological Sciences, Seoul National University
Junichi Takagi: Laboratory for Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Suita
Injin Bang: Department of Biological Sciences, Seoul National University
Hee-Jung Choi: Department of Biological Sciences, Seoul National University

DOI: https://doi.org/10.1038/s42003-022-03370-4
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

Read online

The linker domain of Frizzled receptors has a varying effect on the functional levels of canonical and non-canonical Wnt signaling, with FZD chimeras influencing the binding of Wnt proteins and the recruitment of proteins regulating downstream signaling.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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