Nature Communications (Jul 2019)
Probing the impact of sulfur/selenium/carbon linkages on prodrug nanoassemblies for cancer therapy
- Bingjun Sun,
- Cong Luo,
- Xuanbo Zhang,
- Mengran Guo,
- Mengchi Sun,
- Han Yu,
- Qin Chen,
- Wenqian Yang,
- Menglin Wang,
- Shiyi Zuo,
- Pengyu Chen,
- Qiming Kan,
- Haotian Zhang,
- Yongjun Wang,
- Zhonggui He,
- Jin Sun
Affiliations
- Bingjun Sun
- Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University
- Cong Luo
- Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University
- Xuanbo Zhang
- Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University
- Mengran Guo
- Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University
- Mengchi Sun
- Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University
- Han Yu
- Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University
- Qin Chen
- Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute
- Wenqian Yang
- Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University
- Menglin Wang
- Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University
- Shiyi Zuo
- Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University
- Pengyu Chen
- Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University
- Qiming Kan
- School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University
- Haotian Zhang
- School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University
- Yongjun Wang
- Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University
- Zhonggui He
- Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University
- Jin Sun
- Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University
- DOI
- https://doi.org/10.1038/s41467-019-11193-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
Prodrug-based self-assembled nanoparticles have emerged as an efficient drug delivery system (DDS) for cancer therapy. Here, the authors show that the type of bond in prodrug assemblies influences the efficiency of the DDS on several different levels.
