Complement C3 inhibition by compstatin Cp40 prevents intra- and extravascular hemolysis of red blood cells

• Inge Baas,
• Laura Delvasto-Nuñez,
• Peter Ligthart,
• Conny Brouwer,
• Claudia Folman,
• Edimara S. Reis,
• Daniel Ricklin,
• John D. Lambris,
• Diana Wouters,
• Masja de Haas,
• Ilse Jongerius,
• Sacha S. Zeerleder

Affiliations

Inge Baas

Sanquin Research, Department of Immunopathology, Amsterdam and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

Laura Delvasto-Nuñez

Sanquin Research, Department of Immunopathology, Amsterdam and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands;Department of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

Peter Ligthart

Department of Immunohematology Diagnostics, Sanquin Diagnostic Services, Amsterdam, the Netherlands

Conny Brouwer

Department of Immunohematology Diagnostics, Sanquin Diagnostic Services, Amsterdam, the Netherlands

Claudia Folman

Department of Immunohematology Diagnostics, Sanquin Diagnostic Services, Amsterdam, the Netherlands

Edimara S. Reis

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Daniel Ricklin

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

John D. Lambris

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Diana Wouters

Sanquin Research, Department of Immunopathology, Amsterdam and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

Masja de Haas

Department of Immunohematology Diagnostics, Sanquin Diagnostic Services, Amsterdam, the Netherlands;Center for Clinical Transfusion Research, Sanquin Research, Leiden, the Netherlands;Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands

Ilse Jongerius

Sanquin Research, Department of Immunopathology, Amsterdam and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

Sacha S. Zeerleder

Sanquin Research, Department of Immunopathology, Amsterdam and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands;Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands;Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;Department for BioMedical Research, University of Bern, Bern, Switzerland