Frequency-dependent neural activity in primary angle-closure glaucoma

Abstract

Fei Jiang,1,* Chen Yu,2,* Min-Jing Zuo,1,* Chun Zhang,3 Ying Wang,4 Fu-Qing Zhou,2 Xian-Jun Zeng2 1Department of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China; 2Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, Jiangxi 330006, People’s Republic of China; 3Department of Radiology, Huai An Maternal and Child Health Hospital, Huai An, Jiangsu 223302, People’s Republic of China; 4Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China *These authors contributed equally to this work Objective: In this study, we aimed to investigate the frequency-dependent spontaneous neural activity in primary angle-closure glaucoma (PACG) using the amplitude of low-frequency fluctuations (ALFF) method.Patients and methods: In total, 52 PACG individuals (24 males and 28 females) and 52 normal-sighted controls (NS; 24 males and 28 females) who were closely matched in age, sex, and education underwent resting-state magnetic resonance imaging scans. A repeated-measures ANOVA and post hoc two-sample t-tests were conducted to analyze the different ALFF values in two different frequency bands (slow-4, 0.027–0.073 Hz and slow-5, 0.010–0.027 Hz) between the two groups. Pearson’s correlation analysis was conducted to reveal the relationship between the mean ALFF values and clinical variables in the PACG group.Results: Compared to the NS group, the PACG group had high ALFF values in the right inferior occipital gyrus and low ALFF values in the left middle occipital gyrus, left precentral gyrus, and left postcentral gyrus in the slow-4 band. The PACG group had high ALFF values in the right inferior occipital gyrus and low ALFF values in the left inferior parietal lobule, left postcentral gyrus, and right precentral/postcentral gyrus in the slow-5 band. Specifically, we found that the abnormal ALFF values in the bilateral posterior cingulate gyrus and bilateral precuneus were higher in the slow-4 than in the slow-5 band, whereas ALFF in the bilateral frontal lobe, right fusiform, and right cerebellum posterior lobe were higher in the slow-5 than in the slow-4 band. The greater mean ALFF values of the right inferior occipital gyrus were associated with smaller retinal nerve fiber layer thickness and greater visual fields in PACG group in the slow-4 band.Conclusion: Our results highlighted that individuals in the PACG group showed abnormal spontaneous neural activities in the visual cortices, sensorimotor cortices, frontal lobe, frontoparietal network, and default mode network at two frequency bands, which might indicate impaired vision and cognition and emotion function in PACG individuals. These findings offer important insight into the understanding of the neural mechanism of PACG. Keywords: primary angle-closure glaucoma, amplitude of low-frequency fluctuations, frequency dependent, resting-state magnetic resonance imaging  

Keywords

• primary angle-closure glaucoma
• amplitude of low-frequency fluctuations
• frequency-dependent
• resting-state magnetic resonance imaging