Comparative analisys of ERVWE1 and ERVFRDE1 genes methylation levels in placental tissues in early pregnancy

Abstract

The search of the causes, underlying pathological processes of the human embryogenesis, has the leading position among studies in the field of Human Reproduction. Therefore we conducted analysis of the epigenetic phenomenon, which regulates expression of the genes, involved in the placenta formation processes. It was suggested, that abnormal methylation levels of human endogenous retroviruses ERVWE1 и ERVFRDE1 genes in chorionic tissue of the placenta fetal part can be associated with pathological course and adverse outcome of the pregnancy.

Keywords

• невынашивание беременности
• метилирование
• гены эндогенных вирусов человека
• плацента