Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes

Bruce A. Rheaume; Amyeo Jereen; Mohan Bolisetty; Muhammad S. Sajid; Yue Yang; Kathleen Renna; Lili Sun; Paul Robson; Ephraim F. Trakhtenberg

doi:10.1038/s41467-018-05134-3

Nature Communications (Jul 2018)

Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes

Bruce A. Rheaume,
Amyeo Jereen,
Mohan Bolisetty,
Muhammad S. Sajid,
Yue Yang,
Kathleen Renna,
Lili Sun,
Paul Robson,
Ephraim F. Trakhtenberg

Affiliations

Bruce A. Rheaume: Department of Neuroscience, University of Connecticut School of Medicine
Amyeo Jereen: Department of Neuroscience, University of Connecticut School of Medicine
Mohan Bolisetty: The Jackson Laboratory for Genomic Medicine
Muhammad S. Sajid: Department of Neuroscience, University of Connecticut School of Medicine
Yue Yang: Department of Neuroscience, University of Connecticut School of Medicine
Kathleen Renna: Department of Neuroscience, University of Connecticut School of Medicine
Lili Sun: The Jackson Laboratory for Genomic Medicine
Paul Robson: The Jackson Laboratory for Genomic Medicine
Ephraim F. Trakhtenberg: Department of Neuroscience, University of Connecticut School of Medicine

DOI: https://doi.org/10.1038/s41467-018-05134-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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Retinal ganglion cells (RGCs) are diverse in cellular function and physiology. This study demonstrates additional RGC heterogeneity using single cell transcriptomic analyses to classify 40 classes of RGCs in early postnatal mice before eye opening.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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