Acta Crystallographica Section E (Nov 2010)

2-Fluoro-l-histidine

  • Kiran K. Andra,
  • John C. Bullinger,
  • James G. Bann,
  • David M. Eichhorn

DOI
https://doi.org/10.1107/S1600536810038663
Journal volume & issue
Vol. 66, no. 11
pp. o2713 – o2713

Abstract

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The title compound, C6H8FN3O2, an analog of histidine, shows a reduced side-chain pKa (ca 1). The title structure exhibits a shortening of the bond between the proximal ring N atom and the F-substituted ring C atom, indicating an increase in π-bond character due to an inductive effect of fluorine.