Research advances in the effect of transcranial magnetic stimulation on neuroinflammation in patients with Parkinson’s disease

Abstract

The main pathological features of Parkinson’s disease (PD) are the loss of dopaminergic neurons and the formation of Lewy bodies in the basal ganglia, but its exact etiology remained unknown. A large number of studies have shown that neuroinflammation is closely associated with the development and progression of PD, and the research on inflammation-related mechanisms may help to provide new targets for the prevention and control of PD and search for new treatment strategies. Repetitive transcranial magnetic stimulation (rTMS) can effectively improve the symptoms of PD patients and alleviate neuroinflammation, but further studies are needed to clarify its detailed mechanism. This article summarizes the association of neuroinflammation with the development and progression of PD, analyzes the role of rTMS in the treatment of neuroinflammation in PD, and proposes the future research directions.

Keywords

• parkinson’s disease|inflammation|transcranial magnetic stimulation|microglia|astrocytes|inflammasomes|adaptive immunity|review