Nature Communications (Aug 2019)

WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes

  • Anbang Dai,
  • Li Yu,
  • Hong-Wei Wang

DOI
https://doi.org/10.1038/s41467-019-11694-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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After autophagic cargo degradation, autolysosomes undergo a reformation process to recycle lysosomal membrane components. Here, Dai et al. demonstrate that the actin nucleation promoting factor WHAMM is required for autolysosome reformation by providing an actin scaffold to drive tubulation.