Bioorthogonal Correlative Light-Electron Microscopy of Mycobacterium tuberculosis in Macrophages Reveals the Effect of Antituberculosis Drugs on Subcellular Bacterial Distribution

• Thomas Bakkum,
• Matthias T. Heemskerk,
• Erik Bos,
• Mirjam Groenewold,
• Nikolaos Oikonomeas-Koppasis,
• Kimberley V. Walburg,
• Suzanne van Veen,
• Martijn J. C. van der Lienden,
• Tyrza van Leeuwen,
• Marielle C. Haks,
• Tom H. M. Ottenhoff,
• Abraham J. Koster,
• Sander I. van Kasteren

Affiliations

Thomas Bakkum

Leiden Institute of Chemistry and The Institute of Chemical Immunology, Leiden University, Leiden, The Netherlands

Matthias T. Heemskerk

Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

Erik Bos

Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands

Mirjam Groenewold

Leiden Institute of Chemistry and The Institute of Chemical Immunology, Leiden University, Leiden, The Netherlands

Nikolaos Oikonomeas-Koppasis

Leiden Institute of Chemistry and The Institute of Chemical Immunology, Leiden University, Leiden, The Netherlands

Kimberley V. Walburg

Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

Suzanne van Veen

Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

Martijn J. C. van der Lienden

Leiden Institute of Chemistry and The Institute of Chemical Immunology, Leiden University, Leiden, The Netherlands

Tyrza van Leeuwen

Leiden Institute of Chemistry and The Institute of Chemical Immunology, Leiden University, Leiden, The Netherlands

Marielle C. Haks

Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

Tom H. M. Ottenhoff

Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

Abraham J. Koster

Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands

Sander I. van Kasteren

Leiden Institute of Chemistry and The Institute of Chemical Immunology, Leiden University, Leiden, The Netherlands