Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics

• Clarisse G. Ricci,
• Janice S. Chen,
• Yinglong Miao,
• Martin Jinek,
• Jennifer A. Doudna,
• J. Andrew McCammon,
• Giulia Palermo

Affiliations

Clarisse G. Ricci

†Department of Pharmacology, University of California San Diego, La Jolla, California, United States

Janice S. Chen

∥Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States

Yinglong Miao

Center for Computational Biology and Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States

Martin Jinek

Department of Biochemistry, University of Zürich, Zürich, Switzerland

Jennifer A. Doudna

∥Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States

J. Andrew McCammon

†Department of Pharmacology, University of California San Diego, La Jolla, California, United States

Giulia Palermo

Department of Bioengineering, Bourns College of Engineering, University of California Riverside, Riverside, California, United States