Nature Communications (Apr 2020)

A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division

  • Lovorka Stojic,
  • Aaron T. L. Lun,
  • Patrice Mascalchi,
  • Christina Ernst,
  • Aisling M. Redmond,
  • Jasmin Mangei,
  • Alexis R. Barr,
  • Vicky Bousgouni,
  • Chris Bakal,
  • John C. Marioni,
  • Duncan T. Odom,
  • Fanni Gergely

DOI
https://doi.org/10.1038/s41467-020-14978-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 21

Abstract

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Long noncoding RNAs (lncRNAs) regulate key steps of cell division. Here, the authors perform a comprehensive RNAi imaging screen targeting more than 2,000 human lncRNAs, and suggest a role of chromatin-associated linc00899 in regulation of cell division by suppressing the transcription of microtubule-binding protein TPPP/p25.