Nature Communications (Jan 2020)
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
- Shaza B. Zaghlool,
- Brigitte Kühnel,
- Mohamed A. Elhadad,
- Sara Kader,
- Anna Halama,
- Gaurav Thareja,
- Rudolf Engelke,
- Hina Sarwath,
- Eman K. Al-Dous,
- Yasmin A. Mohamoud,
- Thomas Meitinger,
- Rory Wilson,
- Konstantin Strauch,
- Annette Peters,
- Dennis O. Mook-Kanamori,
- Johannes Graumann,
- Joel A. Malek,
- Christian Gieger,
- Melanie Waldenberger,
- Karsten Suhre
Affiliations
- Shaza B. Zaghlool
- Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar
- Brigitte Kühnel
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Mohamed A. Elhadad
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Sara Kader
- Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar
- Anna Halama
- Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar
- Gaurav Thareja
- Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar
- Rudolf Engelke
- Proteomics Core, Weill Cornell Medicine‐Qatar
- Hina Sarwath
- Proteomics Core, Weill Cornell Medicine‐Qatar
- Eman K. Al-Dous
- Genomics Core, Weill Cornell Medicine-Qatar
- Yasmin A. Mohamoud
- Genomics Core, Weill Cornell Medicine-Qatar
- Thomas Meitinger
- German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance
- Rory Wilson
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Konstantin Strauch
- Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Annette Peters
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Dennis O. Mook-Kanamori
- Department of Clinical Epidemiology, Leiden University Medical Centre
- Johannes Graumann
- Scientific Service Group Biomolecular Mass Spectrometry, Max Planck Institute for Heart and Lung Research, W.G. Kerckhoff Institute
- Joel A. Malek
- Genomics Core, Weill Cornell Medicine-Qatar
- Christian Gieger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Melanie Waldenberger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Karsten Suhre
- Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar
- DOI
- https://doi.org/10.1038/s41467-019-13831-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
DNA methylation is associated with complex traits and the expression of genes and proteins. Here, Zaghlool et al. perform epigenome-wide association studies for 1,123 plasma proteins, replicate obtained protein (p)QTMs in an independent cohort and find overlap of pQTMs with expression QTMs and previously reported disease associations.
