Bone metabolism and RANKL/RANK/OPG trail in periodontal disease

Abstract

Periodontal disease is an inflammatory disease of multifactorial etiology. In order for it to appear there must come to an imbalance between the effects of pathogens and host defense mechanisms. As a result of its course the destruction of structures supporting the teeth appears (periodontium, cement, bone), and consequently leads to teeth loosening and loss. In recent years, the participation of RANKL/RANK/OPG in bone remodeling process was highligted.

Keywords

• bone metabolism
• periodontitis
• rankl/rank/opg
• cytokins