The Ambivalent Role of miRNAs in Carcinogenesis: Involvement in Renal Cell Carcinoma and Their Clinical Applications

Federica Spadaccino; Margherita Gigante; Giuseppe Stefano Netti; Maria Teresa Rocchetti; Rossana Franzin; Loreto Gesualdo; Giuseppe Castellano; Giovanni Stallone; Elena Ranieri

doi:10.3390/ph14040322

Pharmaceuticals (Apr 2021)

The Ambivalent Role of miRNAs in Carcinogenesis: Involvement in Renal Cell Carcinoma and Their Clinical Applications

Federica Spadaccino,
Margherita Gigante,
Giuseppe Stefano Netti,
Maria Teresa Rocchetti,
Rossana Franzin,
Loreto Gesualdo,
Giuseppe Castellano,
Giovanni Stallone,
Elena Ranieri

Affiliations

Federica Spadaccino: Clinical Pathology Unit, Center of Molecular Medicine, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy
Margherita Gigante: Clinical Pathology Unit, Center of Molecular Medicine, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy
Giuseppe Stefano Netti: Clinical Pathology Unit, Center of Molecular Medicine, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy
Maria Teresa Rocchetti: Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy
Rossana Franzin: Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy
Loreto Gesualdo: Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy
Giuseppe Castellano: Nephrology Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy
Giovanni Stallone: Nephrology Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy
Elena Ranieri: Clinical Pathology Unit, Center of Molecular Medicine, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy

DOI: https://doi.org/10.3390/ph14040322
Journal volume & issue: Vol. 14, no. 4
p. 322

Abstract

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The analysis of microRNA (miRNAs), small, non-coding endogenous RNA, plays a crucial role in oncology. These short regulatory sequences, acting on thousands of messenger RNAs (mRNAs), modulate gene expression at the transcriptional and post-transcriptional level leading to translational repression or degradation of target molecules. Although their function is required for several physiological processes, such as proliferation, apoptosis and cell differentiation, miRNAs are also responsible for development and/or progression of several cancers, since they may interact with classical tumor pathways. In this review, we highlight recent advances in deregulated miRNAs in cancer focusing on renal cell carcinoma (RCC) and provide an overview of the potential use of miRNA in their clinical settings, such as diagnostic and prognostic markers.

Published in Pharmaceuticals

ISSN: 1424-8247 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceuticals/

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