The Overlooked Cornerstone in Precise Medicine: Personalized Postoperative Surveillance Plan for NSCLC

Chenyu Jiang, MD; Yang Zhang, MD; Penghao Deng, MD; Han Lin, MD; Fangqiu Fu, MD; Chaoqiang Deng, MD; Haiquan Chen, MD, PhD

JTO Clinical and Research Reports (Aug 2024)

The Overlooked Cornerstone in Precise Medicine: Personalized Postoperative Surveillance Plan for NSCLC

Chenyu Jiang, MD,
Yang Zhang, MD,
Penghao Deng, MD,
Han Lin, MD,
Fangqiu Fu, MD,
Chaoqiang Deng, MD,
Haiquan Chen, MD, PhD

Affiliations

Chenyu Jiang, MD: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; Institute of Thoracic Oncology, Fudan University, Shanghai, People’s Republic of China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
Yang Zhang, MD: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; Institute of Thoracic Oncology, Fudan University, Shanghai, People’s Republic of China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
Penghao Deng, MD: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; Institute of Thoracic Oncology, Fudan University, Shanghai, People’s Republic of China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
Han Lin, MD: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; Institute of Thoracic Oncology, Fudan University, Shanghai, People’s Republic of China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
Fangqiu Fu, MD: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; Institute of Thoracic Oncology, Fudan University, Shanghai, People’s Republic of China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
Chaoqiang Deng, MD: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; Institute of Thoracic Oncology, Fudan University, Shanghai, People’s Republic of China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
Haiquan Chen, MD, PhD: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; Institute of Thoracic Oncology, Fudan University, Shanghai, People’s Republic of China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; Corresponding author. Address for correspondence: Haiquan Chen, MD, PhD, Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, People’s Republic of China.

Journal volume & issue: Vol. 5, no. 8
p. 100701

Abstract

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Non-small cell lung cancer recurrence after curative-intent surgery remains a challenge despite advancements in treatment. We review postoperative surveillance strategies and their impact on overall survival, highlighting recommendations from clinical guidelines and controversies. Studies suggest no clear benefit from more intensive imaging, whereas computed tomography scans reveal promise in detecting recurrence. For early-stage disease, including ground-glass opacities and adenocarcinoma in situ or minimally invasive adenocarcinoma, less frequent surveillance may suffice owing to favorable prognosis. Liquid biopsy, especially circulating tumor deoxyribonucleic acid, holds potential for detecting minimal residual disease. Clinicopathologic factors and genomic profiles can also provide information about site-specific metastases. Machine learning may enable personalized surveillance plans on the basis of multi-omics data. Although precision medicine transforms non-small cell lung cancer treatment, optimizing surveillance strategies remains essential. Tailored surveillance strategies and emerging technologies may enhance early detection and improve patients’ survival, necessitating further research for evidence-based protocols.

Published in JTO Clinical and Research Reports

ISSN: 2666-3643 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.journals.elsevier.com/jto-clinical-and-research-reports/

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