Nature Communications (Jun 2022)
Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders
Abstract
The hippocampus has been associated with memory traits and a variety of neurodegenerative and psychiatric disorders. Here, the authors have done a multivariate GWAS revealing 177 genetic loci, and overlap with various brain disorders may suggest partly age- and disorder-independent mechanisms underlying hippocampal pathology.