Two new cycloartanes from the leaves of Combretum quadrangulare growing in Vietnam and their biological activities

Abstract

Two new cycloartanes, combretanones G and H (1 and 2), were isolated from the leaves of Combretum quadrangulare. Their structures were elucidated by applying a set of spectroscopic methods, while their relative configurations were determined using DFT-NMR chemical shift calculations and subsequent assignment of DP4 probabilities. Compounds 1 and 2 are C-23/C-24 stereoisomers of the previously-reported euphonerin E. Both exhibited moderate cytotoxicity against three human cancer cell lines. Compound 2 was shown to be a potent antiparasitic. Our results confirm the traditional medicinal uses of Combretum quadrangulare in Vietnam.

Keywords

• Combretaceae
• Combretum quadrangulare
• Cycloartane
• Combretanones G and H
• Cytotoxicity
• Antiparasitic activity