Nature Communications (Jun 2019)

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

  • Gerard Minuesa,
  • Steven K. Albanese,
  • Wei Xie,
  • Yaniv Kazansky,
  • Daniel Worroll,
  • Arthur Chow,
  • Alexandra Schurer,
  • Sun-Mi Park,
  • Christina Z. Rotsides,
  • James Taggart,
  • Andrea Rizzi,
  • Levi N. Naden,
  • Timothy Chou,
  • Saroj Gourkanti,
  • Daniel Cappel,
  • Maria C. Passarelli,
  • Lauren Fairchild,
  • Carolina Adura,
  • J. Fraser Glickman,
  • Jessica Schulman,
  • Christopher Famulare,
  • Minal Patel,
  • Joseph K. Eibl,
  • Gregory M. Ross,
  • Shibani Bhattacharya,
  • Derek S. Tan,
  • Christina S. Leslie,
  • Thijs Beuming,
  • Dinshaw J. Patel,
  • Yehuda Goldgur,
  • John D. Chodera,
  • Michael G. Kharas

DOI
https://doi.org/10.1038/s41467-019-10523-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.