Endocrine Regulations (Jul 2016)

Inhibition of IRE1 signaling affects the expression of genes encoded glucocorticoid receptor and some related factors and their hypoxic regulation in U87 glioma cells

  • Minchenko D.O.,
  • Riabovol O.O.,
  • Tsymbal D.O.,
  • Ratushna O.O.,
  • Minchenko O.H.

DOI
https://doi.org/10.1515/enr-2016-0014
Journal volume & issue
Vol. 50, no. 3
pp. 127 – 136

Abstract

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Objective. The aim of the present investigation was to examine the effect of inhibition of endoplasmic reticulum stress signaling, mediated by IRE1 (inositol requiring enzyme 1), which is a central mediator of the unfolded protein response on the expression of genes encoding glucocorticoid receptor (NR3C1) and some related proteins (SGK1, SGK3, NCOA1, NCOA2, ARHGAP35, NNT) and their hypoxic regulation in U87 glioma cells for evaluation of their possible significance in the control of the glioma growth.

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